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Monday, January 21, 2019

Hemoglobin Model

Hemoglobin model vizor the 02 being carried by mite. Pipe cleaners=subunits Green marsh eminent=iron molecule Yellow marsh mellow=oxygen molecule Orange cards= heme groups (wolfe, 2000)Oxygenated/deoxygenated oxygenated 02 bound Bright red subunit is in relaxed form Higher relationship for 02 Affinity for oxygen iscooperative, which corethat the chemical attraction for 02increases with each boundmolecule. ( Ahern & Rajagopal, 2013)Deoxygenated 02 not bound fantasm red color In tense form which has lower similarity for oxygen. When 02 binds todeoxygenated hemoglobin,hemoglobin transitions from Tstate to R state. This occurswhen 02 binds to iron, itcauses a change in thesubunit. ( Ahern & Rajagopal,2013)Bohr Effect Hemoglobin has a graduate(prenominal) kinship for 02 at a high PH, low Co2. Hemoglobin has a lower affinity at a low PH, high Co2.At a high Co2, low PH hemoglobin is more stable in the T state which decreases its affinity for 02. Oxygen needs to be d elivered to the tissues. Tissues have a low PH. Hemoglobin needs to release 02 at low PH. funky PH = low 02 saturation.( Wolfe,2000 )Myoglobin wants to store 02 for when tissues need it. Has a higher affinity than hemoglobin. ( Ahern & Rajagopal, 2013) Hemoglobin wants to unload 02 in the tissues. Has a lower affinity than myoglobin. ( Ahern & Rajagopal, 2013 )(Genetic science learning center, 2013)Difference between normal and reap hook forms of hemoglobin.Normal and sickle erythrocytes at the cellular level.(Genetic science learning center, 2013)Diseased RBCs vs. Normal RBCs Diseased Have a sickle shape, and arethick and sticky. Clumpstogether in small crinklevessels. Blocks normal hemoglobinto deliver 02 to tissues. Short life suspender of 10-20 days Body can not keep up with rbc production leading toanemia and pain. (Wolfe,2000)Normal Round Doughnut shape Life span of 120 days (Wolfe, 2000)(Ahern and Rajagopal, 2013)

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